About The Wei Lab
Who are we?
We are a functional genomics lab at Mass General Brigham. We employ single-cell RNA sequencing, spatial transcriptomics, and patient-derived organoids to decipher the stromal context of inflammatory and fibrotic diseases. Our long-term goal is to find new therapies for patients suffering from inflammatory and fibrotic diseases.
Lab Update 9/10/2026
Congratulations to Alvin and Lennard for publishing their paper in KI Reports! In full collaboration with Shruti Gupta, we applied Xenium Prime 5K spatial transcriptomics to characterize mechanisms of checkpoint-inhibitor-associated interstitial nephritis
Lab Update 7/8/2026
Congratulations to Kseniia Anufrieva Neda Shahriari, MD for publishing their paper in Nature Communications! In full collaboration with Ruth Ann Vleugels MD, MPH, MBA, Mehdi Rashighi, MD, and Sizun Jiang, we applied Xenium Prime 5K spatial transcriptomics from 10x Genomics to uncover spatial niches enriched in patients with cancer-assoc
Congratulations to Kseniia Anufrieva Neda Shahriari, MD for publishing their paper in Nature Communications! In full collaboration with Ruth Ann Vleugels MD, MPH, MBA, Mehdi Rashighi, MD, and Sizun Jiang, we applied Xenium Prime 5K spatial transcriptomics from 10x Genomics to uncover spatial niches enriched in patients with cancer-associated dermatomyositis (DM). Our study introduces the first translation of a spatially resolved multicellular transcriptomic signature in DM skin biopsies.
Lab Update 3/16/2026
New preprint! Vikram and Alvin found a critical role for neurotrophins and NTRK receptors in sustaining abnormal vascular maturation in RA synovia. Importantly, FDA-approved NTRK inhibitors effectively reverse RA vascular maturation and reduce blood vessel density in RA synovial explants. Our study highlights a novel role for neurotrophin
New preprint! Vikram and Alvin found a critical role for neurotrophins and NTRK receptors in sustaining abnormal vascular maturation in RA synovia. Importantly, FDA-approved NTRK inhibitors effectively reverse RA vascular maturation and reduce blood vessel density in RA synovial explants. Our study highlights a novel role for neurotrophins during fibroblast to vascular mural cell differentiation and raises the possibility of repurposing NTRK inhibitors for RA treatment.
Lab update 1/16/2026
Congratulations Kartik Bhamidipati and Alexa McIntyre, for publishing their study on defining the cellular and molecular mechanisms of refractory rheumatoid arthritis in Nature Immunology!
Lab Update 12/13/2025
A preprint of our story on how fibroblasts sense cell density to restore synovial lining during rheumatoid arthritis remission is now online!