The Wei Lab @ Brigham and Women's Hospital
fibroblasts, spatial transcriptomics, and organoids.
The Wei Lab @ Brigham and Women's Hospital
fibroblasts, spatial transcriptomics, and organoids.
About The Wei Lab
Who are we?
Lab Update 3/16/2026
Lab Update 3/16/2026
We are a functional genomics lab at Brigham and Women's Hospital.. We employ single-cell RNA-sequencing, spatial transcriptomics, and patient-derived organoids to decipher the stromal context of inflammatory and fibrotic diseases.
Lab Update 3/16/2026
Lab Update 3/16/2026
Lab Update 3/16/2026
New preprint! Vikram and Alvin found a critical role for neurotrophins and NTRK receptors in sustaining abnormal vascular maturation in RA synovia. Importantly, FDA-approved NTRK inhibitors effectively reverse RA vascular maturation and reduce blood vessel density in RA synovial explants. Our study highlights a novel role for neurotrophin
New preprint! Vikram and Alvin found a critical role for neurotrophins and NTRK receptors in sustaining abnormal vascular maturation in RA synovia. Importantly, FDA-approved NTRK inhibitors effectively reverse RA vascular maturation and reduce blood vessel density in RA synovial explants. Our study highlights a novel role for neurotrophins during fibroblast to vascular mural cell differentiation and raises the possibility of repurposing NTRK inhibitors for RA treatment.
Lab update 1/16/2026
Lab Update 3/16/2026
Congratulations Kartik Bhamidipati and Alexa McIntyre, for publishing their study on defining the cellular and molecular mechanisms of refractory rheumatoid arthritis in Nature Immunology!
Lab Update 12/13/2025
A preprint of our story on how fibroblasts sense cell density to restore synovial lining during rheumatoid arthritis remission is now online!
Lab Update 11/21/2025
In collaboration with Sami Farhi and Britt Good, our imaging spatial transcriptomics benchmarking paper is online in Nature Communications
Lab Update 11/4/2025
In collaboration with Shruti Gupta, Deepak Rao, and Lennard Ostendorf, we are excited to share a preprint of Alvin and Lennard's manuscript on spatial transcriptomics analysis of checkpoint-inhibitor-induced interstitial nephritis.